A provider prescribes filgrastim 5 mcg/kg/day to stimulate the production of neutrophils, a type of white blood cell that fights infection. Filgrastim is a granulocyte colony-stimulating factor (G-CSF) that works by binding to receptors on the surface of neutrophil precursors, causing them to divide and mature.
It is used to treat neutropenia, a condition in which the body does not have enough neutrophils.
Filgrastim is typically administered subcutaneously or intravenously once daily. The dosage is determined by the patient’s weight and the severity of their neutropenia. The most common side effects of filgrastim are bone pain, headache, fatigue, and nausea.
Filgrastim: Drug Overview
Filgrastim is a recombinant granulocyte colony-stimulating factor (G-CSF) that stimulates the production and release of neutrophils from bone marrow. It is indicated for:
- Neutropenia in patients with non-myeloid malignancies receiving myelosuppressive chemotherapy
- Severe congenital neutropenia (SCN)
- Cyclic neutropenia
- Idiopathic neutropenia
Common side effects of filgrastim include:
- Bone pain
- Headache
- Nausea
- Vomiting
Dosage and Administration, A provider prescribes filgrastim 5 mcg/kg/day
The recommended dosage of filgrastim for different indications varies. For neutropenia in patients with non-myeloid malignancies receiving myelosuppressive chemotherapy, the usual dosage is 5 mcg/kg/day subcutaneously.
Filgrastim is typically administered subcutaneously once daily. The frequency of injections may vary depending on the indication and patient’s response.
During filgrastim therapy, monitoring of white blood cell counts and platelet counts is recommended.
Special Considerations
Filgrastim is contraindicated in patients with:
- Known hypersensitivity to filgrastim or E. coli-derived proteins
- Acute myeloid leukemia (AML)
Filgrastim should be used with caution in patients with:
- Pre-existing cardiac conditions
- Sickle cell disease
- History of splenomegaly or splenic infarction
Filgrastim may interact with other medications, such as:
- Chemotherapy drugs
- Immunosuppressive drugs
- Anti-inflammatory drugs
Patient Education
Purpose of Filgrastim:Filgrastim helps your body produce more white blood cells to fight infections.
Administration:Filgrastim is given as an injection under the skin (subcutaneously). It is usually given once a day.
Potential Side Effects:Filgrastim may cause side effects, such as bone pain, headache, nausea, and vomiting. Tell your doctor if you have any of these side effects.
Importance of Adherence:It is important to take filgrastim exactly as prescribed by your doctor. Do not skip any doses or stop taking filgrastim without talking to your doctor.
Signs and Symptoms of Complications:If you experience any severe side effects, such as chest pain, shortness of breath, or fever, seek medical attention immediately.
Quick FAQs: A Provider Prescribes Filgrastim 5 Mcg/kg/day
What is filgrastim?
Filgrastim is a granulocyte colony-stimulating factor (G-CSF) that stimulates the production of neutrophils, a type of white blood cell that fights infection.
What is filgrastim used for?
Filgrastim is used to treat neutropenia, a condition in which the body does not have enough neutrophils.
How is filgrastim administered?
Filgrastim is typically administered subcutaneously or intravenously once daily.
What are the side effects of filgrastim?
The most common side effects of filgrastim are bone pain, headache, fatigue, and nausea.
